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Presented for research literature review only Zarth AT et al

It also modulates dopamine and serotonin pathways

TB4 (Thymosin Beta-4) is a naturally occurring peptide found throughout the body that regulates actin dynamics, recruits stem cells and progenitor cells to injury sites, reduces inflammation, and drives new blood vessel formation

Studies which make use of phosphocreatinine/creatinine for this purpose may suffer from methodological error given the reported negative association between creatinine levels and depression scores (Faulkner et al

Bipolar disorder: A landmark RCT (n=75) found that NAC (1,000 mg twice daily for 24 weeks) produced a significant improvement in depression scores (Montgomery-Asberg Depression Rating Scale) in bipolar disorder as an adjunct to usual treatment (Berk et al., Biol Psychiatry, 2008) [74]